منابع مشابه
Steroid Therapy in Adrenal Insufficiency
Addison’s disease or autoimmune adrenalitis: These are autoimmune conditions, constituting 80% of all cases. Autoimmune adrenalitis may be part of Type 2 autoimmune polyglandular syndrome, which can include type 1 diabetes, hyperthyroidism, and autoimmune thyroid disease (also known as Hashimoto’s thyroiditis), and Hashimoto’s disease. Hypogonadism may also present with this syndrome. Other dis...
متن کاملHydroxylation and sulfation of sex steroid hormones in inflammatory liver
Sex steroids, also known as gonadal steroids, are oxidized with hydroxylation by cytochrome P450, glucuronidation by UDP-glucuronosyltransferase, sulfation by sulfotransferase, andO-methylation by catechol O-methyltransferase. Thus, it is important to determine the process by which inflammation influences metabolism of gonadal hormones. Therefore, we investigated the mechanism of metabolic enzy...
متن کاملDiagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors
Radiological examination may unexpectedly reveal an adrenal mass. Current algorithms for differentiating between benign and malignant lesions mainly rely on size and densitometry on unenhanced CT, which have limited specificity. We examined the diagnostic value of urinary steroid profiling by gas chromatography/mass-spectrometry (GC/MS) in differentiating between benign and malignant adrenal tu...
متن کاملUrine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors
CONTEXT Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2-11% of incidentally discovered adrenal masses. Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predicti...
متن کاملMatrix relevance LVQ in steroid metabolomics based classification of adrenal tumors
We present a machine learning system for the differential diagnosis of benign adrenocortical adenoma (ACA) vs. malignant adrenocortical carcinoma (ACC). The data employed for the classification are urinary excretion values of 32 steroid metabolites. We apply prototypebased classification techniques to discriminate the classes, in particular, we use modifications of Generalized Learning Vector Q...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2021
ISSN: 0021-972X,1945-7197
DOI: 10.1210/clinem/dgab182